When considering your mental health treatment options, a common choice is Sertraline (sertraline hydrochloride), known by the brand name Zoloft. Another is Fluoxetine, known by the brand name Prozac.

Both are SSRI (selective serotonin reuptake inhibitors) medications. They work by inhibiting reuptake, making the neurotransmitter serotonin more available. Healthcare providers prescribe them for several mental health conditions, including major depression.